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Active ingredient | Glyphosate | ||||
Chemical name | N-(phosphonomethyl)glycine | ||||
Classification | Herbicide / Agrochemical | ||||
Biochemistry | Inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), an enzyme of the aromatic acid biosynthetic pathway. This prevents synthesis of essential aromatic amino acids needed for protein biosynthesis. | ||||
Mode of action | Non-selective systemic herbicide, absorbed by the foliage, with rapid translocation throughout the plant. Inactivated on contact with soil. | ||||
Usage | Control of annual and perennial grasses and broad-leaved weeds, pre-harvest, in cereals, peas, beans, oilseed rape, flax and mustard, at c. 1.5-2 kg/ha; control of annual and perennial grasses and broad-leaved weeds in stubble and post-planting/pre-emergence of many crops; as a directed spray in vines and olives, at up to 4.3 kg/ha; in orchards, pasture, forestry and industrial weed control, at up to 4.3 kg/ha. As an aquatic herbicide, at c. 2 kg/ha. | ||||
Mammalian Toxicology | Oral Acute oral LD50 for rats 5600, mice 11 300, goats 3530 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >5000 mg/kg. Eye irritant; non-irritating to skin (rabbits). Inhalation LC50 (4 h) for rats >4.98 mg/l air. | ||||

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