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What is Ceftriaxone sodium ?
Ceftriaxone (INN) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is commonly used in febrile infants between 4 and 8 weeks of age who are admitted to the hospital to exclude sepsis. The dosage for acute ear infection in the very young is 50 mg/kg IM, one dose daily up to three days. It has also been used in the treatment of Lyme disease, typhoid fever, and gonorrhea.Intravenous dosages may be adjusted for body mass in younger patients and is administered every 12–24 hours, at a dose that depends on the type and severity of the infection.For the treatment of gonorrhea, a single intramuscular injection is usually given. According to the Journal of Family Practice, Volume 60, NO 12, December 2011, the intramuscular dose of ceftriaxone (Rocephin) has been increased from 125 mg IM to 250 mg IM due to increasing resistance of the gonococcal bacteria. It is also recommended that 100 mg of doxycycline be given orally at the same time for dual treatment. This takes care of treatment of underlying chlamydia, since treatment for chlamydia infection is also recommended. It must not be mixed or administered simultaneously (within 48 hours) with calcium-containing solutions or products for patients younger than 28 days old,even via different infusion lines (rare fatal cases of calcium-ceftriaxone precipitates in lung and kidneys in neonates have been described).To reduce the pain of intramuscular injection, ceftriaxone may be reconstituted with 1% lidocaine.Ceftriaxone has also been investigated for efficacy in preventing relapse to cocaine addiction.Ceftriaxone seems to increase EAAT2 pump expression and activity in the central nervous system and has therefore a potential to reduce glutamatergic toxicity.Ceftriaxone has been shown to have neuroprotective properties in a number of neurological disorders, including spinal muscular atrophy and amyotrophic lateral sclerosis.
How dose the Ceftriaxone sodium works?
Ceftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls.
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Shaanxi Top Pharm Chemical Co., Ltd. has been primarily engaged in the research, development, and marketing of various photochemical products since 1999. We take full advantages of natural pharmaceutical resources
which grow in the areas of Qinba Mountain and Qinling Mountain. Within years' development, our core competitiveness has been firmly formed and developed.
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