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Specification of Oxytetracycline Hcl
| Items | Specifications | Results | |
| Characters | Yellow, Crystalline Powder | Conform | |
| Solubility | Freely soluble in water, Sparingly soluble in alcohol | Conform | |
| Identification | A: Thin-layer chromatography results | Conforms | |
| B: Colour reaction with sulfuric acid | Conforms | ||
| C: Give reaction (a) of chlorides | Conforms | ||
| pH | 2.3~2.9 | 2.5 | |
| Specific optical rotation | -188~-200 | -196 | |
| Specific absorbance | 270~290 | 283 | |
| Light | 430nm | ≤0.50 | 0.18 |
| 490nm | ≤0.20 | 0.04 | |
| Related substances (%) | Impurity A | ≤0.5 | 0.26 |
| Impurity B | ≤2.0 | 0.47 | |
| Impurity C | ≤2.0 | 1.7 | |
| Total of impurities D. E and F | ≤2.0 | 0.2 | |
| Disregard limit | ≤0.1 | conform | |
| Heavy metals (ppm) | ≤50 | <50 | |
| Water(%) | ≤2.0 | 1.2 | |
| Sulfated ash(%) | ≤0.5 | 0.24 | |
| Assay (%) | 95.0~102.0 | 97.3 | |
| Methanol(ppm) | ≤3000 | 632 | |
| Conclusion | The results can conforms with BP2011 | ||
Use for Oxytetracycline hcl
1) Oxytetracycline Hcl is a broad-spectrum antibiotic, active against a wide variety of bacteria.
2) Oxytetracycline Hcl is used to treat infections causd by Chlamydia (e.g the chest infectionpsittacosis, the
eye infection trachoma, and the genital infection urethritis) and infections caused by Mycoplasma organisms
3) Oxytetracycline Hcl is also used to treat acne.
4) Oxytetracycline may also be used to treat other rarer infections, suche as those caused by a group of micro-
organisms called rickettsiae.
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