Description: Dehydroepiandrosterone (DHEA) is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.
In vitro: Dehydroepiandrosterone (DHEA) (10-100 nM for 6-8 hours) protects primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). DHEA also reduces NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) is higher than that of DHEA (10 nM). DHEA (100 nM) protects cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. DHEA produces much greater levels of IL 2 than normals in response to stimulation. DHEA causes an enhanced capacity to secrete IL 2 following activation. DHEA augmentes IL 2 production by activated cloned T cell line. DHEA increases the length of neurites containing the axonal marker Tau-1, and the incidence of varicosities and basket-like process formations in a dose-dependent fashion in primary cultures of mouse embryonic neocortical neurons. DHEA rapidly increases free intracellular calcium via activation of N-methyl-D-aspartate (NMDA) receptors. Dehydroepiandrosterone regulates the motility and/or growth of neocortical neurons.
In vivo: Dehydroepiandrosterone(DHEA), which results in plasma levels that resembled those in young adult humans, protects hippocampal CA1/2 neurons against unilateral infusions of 5 or 10 nmol of NMDA.
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