Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection.
According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over quinine as the treatment of choice for falciparum malaria.
Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6–9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135–137C).
Product Function
Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin. Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria. Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite. Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum.
It is unstable in neutral solution and is therefore only available for injections as artesunic acid. The injectable formulation must be prepared immediately before use in 5% (w/v) sodium bicarbonate solution to produce the salt sodium artesunate
Q: Is the product naturally extracted?
A: Yes, it is 100% naturally extracted.
Q :What is the MOQ ?
A :We welcome small quantity for testing. MOQ is 100g!
Q :Can I mix different Spec.?
A Sure!
Q Can I add or delete items from my order if I change my mind?
A :Yes!
Q When you ship my order?
A :Normally 2 days after receiving your payment, but it can be negotiated based on order quantity. Hope you could understand!
Q :How about the expiry period?
A :Two years!
Q :How can you guarantee the production quality?
A :We have more than ten years experience. We have strictly quality control system in our production process. We have 4 times inspection for each finished product before package.
