ubiquinol 992 78 9 reduced coenzyme q10

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Product Overview

Description

Reduced Coenzyme Q10 (Ubiquinol)     992-78-9


CAS No.: 992-78-9

Mol. Formula: C59H92O4

Mol. Weight: 865.37



Other names : 

Reduced CoQ10

unoxidized CoQ10

CoQ10H2

dihydroquinone


Appearance : off-white powder

Melting point : 45.6 °C (114.1 °F; 318.8 K)
Solubility in water : practically insoluble in water

Ubiquinol is an electron-rich (reduced) form of coenzyme Q10.

The natural ubiquinol form of coenzyme Q10 is 2,3-dimethoxy-5-methyl-6-poly prenyl-1,4-benzoquinol, where the polyprenylated side-chain is 9-10 units long in mammals. Coenzyme Q10 (CoQ10) exists in three redox states, fully oxidized (ubiquinone), partially reduced (semiquinone or ubisemiquinone), and fully reduced (ubiquinol). The redox functions of ubiquinol in cellular energy production and antioxidant protection are based on the ability to exchange two electrons in a redox cycle between ubiquinol (reduced) and the ubiquinone (oxidized) form.

Because humans can synthesize ubiquinol, it is not classed as a vitamin.

Bioavailability
It is well-established that CoQ10 is not well absorbed into the body, as has been published in many peer-reviewed scientific journals. Since the ubiquinol form has two additional hydrogens, it results in the conversion of two ketone groups into hydroxyl groups on the active portion of the molecule. This causes an increase in the polarity of the CoQ10 molecule and may be a significant factor behind the observed enhanced bioavailability of ubiquinol. Taken orally, ubiquinol exhibits greater bioavailability than ubiquinone.

Content in foods
In foods, there are varying amounts of ubiquinol. An analysis of a range of foods found ubiquinol to be present in 66 out of 70 items and accounted for 46% of the total coenzyme Q10 intake (in the Japanese diet). The following chart is a sample of the results.

Molecular aspects
Ubiquinol is a benzoquinol and is the reduced product of ubiquinone also called coenzyme Q10. Its tail consists of 10 isoprene units.

Ubiquinol
The reduction of ubiquinone to ubiquinol occurs in Complexes I & II in the electron transfer chain. The Q cycle[7] is a process that occurs in cytochrome b, a component of Complex III in the electron transport chain, and that converts ubiquinol to ubiquinone in a cyclic fashion. When ubiquinol binds to cytochrome b, the pKa of the phenolic group decreases so that the proton ionizes and the phenoxide anion is formed.

Ubiquinol, semiphenoxide
If the phenoxide oxygen is oxidized, the semiquinone is formed with the unpaired electron being located on the ring.

Ubiquinol
A page on Proteopedia, Complex III of Electron Transport Chain, contains rotatable 3-D structures of Complex III, which may be used to study the peptide structures of Complex III and the mechanism of the Q cycle.

Quality
Product 
Reduced Coenzyme Q10 (Ubiquinol)
Item
Specifications
Assay (C59H92O4) On anhydrous basis
≥95.0%
Identification
IR
Melting point
48℃
Water
≤2.0%
Residue on ignition
≤0.1%
Chromatographic purity
(1) Heavy metals 
≤0.002%
(2) Ubidecarenone 
≤5.0%
(3) Other related substances 
≤1.0%
Microbial limits tests
Total Aerobic Microbial Count
≤1000 CFU/g
Yeasts & Molds (CFU/g)
≤100 CFU/g
E. Coli
Negative
Appearance
A white to yellow crystalline powder
Characteristic
Odorless and no taste
Packing 
Pack in aluminium-pot and two plastic-bags inside.

Storage
1. Store in a well-closed place with constant low temperature and no direct sun light.

2. 3 years when properly stored.
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Payment Methods

T/T(Telex transfer), Western Union, Moneygram, L/C(Letter of Credit), D/P(Documents against Payment)
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Packing

25kg /drum, double plastic bag of foodstuff inside, cardboard drum outside 

or at customer's request.


Storage conditions
Store in a well-closed place with constant low temperature and no direct sun light. Protect from moisture.

Delivery
From chinese warehouse: about 1-6 workdays after payment confirmed.
Usually " in stock" orders can be dispatched within 3 working days. If ordered items are out of stock within 10 days and can't be dispatched in 3 days, we will advise you ASAP, you can change the order or cancel the order ( full amount will be refund)

FAQ

Q1: Can I get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders ?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information.

Q3: How to confirm the Product Quality before placing orders?

A:Free samples can be sent to you for testing and confiramton quality

B: Production according to your specifition  

Q4:Is there a discount?

A:Different quantity has different discount.

Q5: How do you treat quality complaint?

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

company introduce

Shanghai Soyoung has R&D Center and Testing Center, and has international advanced facilities of HPLC, GC, AAS, UV, TLC, LC-MS and IR equipments.

Shanghai Soyoung has nearly 20 years production experience, it is producing in our GMP workshop, each batch pass strict testing before shipment. Strict quality control is performed in every procedure from material sourcing, processing and testing to packing. we can gurantee quality.

Company name
Shanghai Soyoung Biotechnology Inc.
Main Products
health care ingredients
Location
Shanghai,China
Business Type
Manufacturer & Trader
Year start exporting
2011
Number of employees
60-70 people
Factory area
18,000 square meters
Total annual sales volume
US$3,000,000-5,000,000
Main Markets
America,Europe,Mid East,Asia,South Africa and etc.
Certifications
GMP,DMF,ISO,HACCP,Kosher
Our advantages
1. 20 years specialized in healthcare products field.
2. GMP/ISO certificated factory and stable supply chain.
3. Quality first, strictly control before shipment.
4. Custom synthesis by more than 15 professional chemists.
5. Small order,free sample and one step service available.
6. Rapid delivery, 1-6 workdays from China or USA.
7. Support 7 days refund money in case delay shipment.
8. Alibaba assessed supplier & 8 years gold supplier.
5.1921 s.