white crystal powder Cooling agent ws 3/Koolada /ws3 CAS NO.39711 79 0
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- Supplier: Shaanxi Tai Ma Health Biological Co. Ltd.
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Product Overview
Description
Product Properties
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
Product Name: Cooling agent ws-3
Chemical Name: N-Ethyl-2-(isopropyl)-5-methylcyclohexanecarboxamide
CAS No.: 39711-79-0
MF: C13H25NO
MW: 211.35
Appearance: White crystal powder
Odor: Mild cooling, slight menthol odor (almost odorless)
Detection Method: HPLC
Purity: ≥99%
Melting Point: 87-102ºC
Flash Point: >100℃
Specific Rotation: -49 ~ -54°
Water Solubility: Insoluble
EINECS No.: 254-599-0
Series | |
Cooling agent WS-23 | ws23 |
Cooling agent WS-5 | WS5 |
Cooling agent WS-3 | WS3 |
Packing & Delivery
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
Package: 1kg per bag with double plastic inside and aluminium foil bag outside, or 25kg per fibre drum with double plastic bag inside, or according to customers' requirement.
Storage: Store in cool & dry place. Keep away from strong light and heat.
Delivery: 5-8 working days after payment/FedEx, DHL, TNT, EMS, etc.
Detailed Description
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
Background:WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM [1].
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a Ca2+- and Na+-permeable ion channel and is activated by cooling agents and cold temperatures. TRPM8 belongs to TRP family and is expressed in sensory neurons.
WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK293 cells expressed recombinant mouse TRPM8, WS 3 (30 μM) increased [Ca2+]i. WS 3 exhibited potency with EC50 value of 3.7 μM and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 3 was efficacious in eliciting cooling sensation [2].
References:
[1]. Behrendt HJ, Germann T, Gillen C, et al. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol, 2004, 141(4): 737-745.
[2]. Klein AH, Iodi Carstens M, McCluskey TS, et al. Novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. Chem Senses, 2011, 36(7): 649-658.
Advantages
Food Grade Cooling Agent ws-3 For Oral Product
1. There is a high cooling effect without other unpleasant feelings such as bitterness, burning, stinging or tingling sensations and can bring more stimulative, fresh and aromatic sensory to
the entire mouth and throat.
2. Cooling agent ws-3 can solve the difficulty of developing new products with bad sensation.
3. When used with other flavors, it enhances the effects of the flavors. It also can be used with
other cooling agents.
4. Cooling agent ws-3 is water-solubility is no more than 0.1%, it’s better than traditional cooling agents, so it can act on taste bud more wallop and has long cooling effect.
Functions
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
2. Heat-Resistance: Heating under 200oC will not reduce the cooling effect, suitable to use on baking and other high temperature heating process.
3. Its cooling intensity can maintain 15-30 minutes, enriching the refreshing of product and having no burning pain, stabbing and numbness, it’s cooler than traditional Menthol products.
4. Low dosage: 30-100 mg/kg dosage will give good cooling effect.
5. Excellent compatibility with other flavors, it can enhance the effect of the flavors. It also can be combined using with other cooling agents.
Applications
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
1. Daily use products: toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower cream.2. Food products: confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage,
Chewing Gum.
3. Medicine: linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavity
acesodyne, heatstroke pill.
4. Others: cigarette, filter tip and other tobacco, it also can be used for driving insects.
Usage:
1. Soluble in Ethanol/PG firstly, then adding water solution.
2. Or dissolved in flavors firstly, then added into your products.
3. Mixed with dementholized peppermint oil can increase the fragrance signally.
Company Profile
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
Xi’an Taima Biological Co., Ltd. was founded in 2008, is a technological export-oriented private enterprise with the Rights of Self-Managed Import and Export, specializing in active ingredients modernized and industrialization research, development, production, and sales of natural medical botany.
Our factory covers an area of 6,000 square meters equipped with advanced equipment and the production process
Since its inception, the company is aiming at providing every customer with top best quality products and superior service at a reasonable and competitive price, all the time. And in the past 9 years, we’ve gained great progress.
Our products are exported to countries all over the world: USA, countries in North America, South America, European countries like UK, Germany, Sweden, Greece, Finland, Norway, France, Italy, Russia, Ukraine, Estonia, Spain, Latvia, etc. Asia countries like Malaysia, Indonesia, South Korea, Thailand, Philippines, Vietnam, Singapore, etc. Our products are selling very well in these areas. And other countries like Australia, Mexico, Salvatore, Costa Rica, and so on. What’s more, for the high quality products and superior service we provide, we’ve been highly appreciated by our customers. We are getting more and more returning customer day by day.
& Our Company always persist in:
Top Quality Products, Excellent Professional Knowledge, Superior Service
How to Order
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
1. Make sure your quantity need and Leave us message, with your mailed details shown: Including contact name, address information, contact phone, etc.
2.\tWe send you a PI (Proforma Invoice) for price and payment detail.
3.\tPayment by Paypal or Western Union or T/T.
4.\tWe arrange the delivery and update you the tracking number in time.
FAQ
white crystal powder Cooling agent ws-3/Koolada /ws3 CAS NO.39711-79-0
Q1: Could you provide free sample for test?
A1: We can provide you free sample for test, and you only need to pay the delivery cost.
Q2: Which payment terms do you accept?
A2: PayPal, T/T, West Union, Bank Transfer, etc.
Q3: What's about the MOQ ?
A3: It depends on different products. Usually our MOQ is 5kg.
Q4: What’s the delivery lead time?
A4: We will make delivery within 5-8 days after receiving payment.
Q5: What about the delivery port?
A5: Main ports in China are available.
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