catalyst fermentation system with agitator, pH, DO, temperature control

The single-use, SiDoLim bioreactor was an easy-to-use, flexible, and cost-efficient alternative to stainless steel bioreactors, which require continuous time-consuming cleaning and validation between batches.

Today, our bioreactors has been developed to consist of fully integrated systems with intelligent control software and advanced sensor technology. This combination results in bioreactors that are both easy-to-use and reliable to help you maximize the output, and save time and costs.

The SiDoLim Bioreactor system is a versatile system designed for use in both R & D and production. It is a modular system consisting of a base unit with various integral options suitable for culture of multiple cell lines.

Features:

1. Convenience: Presterilized, single-use bioreactors protect against the risk of cross-contamination, require no cleaning, and involve minimal validation and they are supplied in a ready-to-use format
2. Reliability: bioreactors, including all fittings and filters, are supplied sterile and ready for use. They are suitable for cGMP commercial production and a biosafety cabinet is not required for inoculation or sampling
3. Flexibility: Multiple instrument configurations for suspension, microcarrier, batch, fed-batch, or perfusion culture
4. Versatility: The systems are capable of handling culture volumes from 100 mL to 1000 L, 1000L- 50T.

The SiDoLim Bioreactor system has an extensive line of instrumentation such as weight controllers for perfusion culture, dissolved oxygen, amplifier, and pH control.

For bench top operation, covering the bioreactor with a lid is recommended. This prevents accidental damage to the bag. A filter heater for the exhaust filter is strongly recommended otherwise water will condense in the filter and may lead to clogging and over pressure in the bioreactor.

Difference between Bioreactor and Fermentor

Fermenter - can mean either the enzyme or the fermentation apparatus, whereas fermentor can only be used to mean the apparatus.

Fermentor - for bacterial or fungal cells

Bioreactor - for mammalian and insect cells

Bioreactor vs Fermentor

The fermentation is a process that was known to the humans very early as compared to the bioreactor.  The history says that for thousands of years, the mankind was well aware with the process of fermentation. Its scientific studies were first time done in 1850’s by the famous French scientist Louis Pasteur while studding the formation of lactic acid. The importance of the fermentors and bioreactors is at the top as both of these devices perform the activities of living organisms.  The method of the fermentation was mostly used for the production of the brewing alcoholic beverages particularly in earlier times. At the present time, the fermentors are employed for more productive uses. The utilization of the Bioreactors has a greater scope as compared to the fermentors as the bioreactor perform the process of designing and construction as well. The systems which are utilized for the prime purpose of enhancing the growth and maintenance of a population of bacterial or fungal cells in a controlled mode are given by the fermentors. In contrast, it is the bioreactor system that is responsible for growth and maintenance of the mammalian and insect cells only. Despite this major difference, you will find more prominent dissimilarities between the motives of the fermentors and the bioreactor in sterilization process in particular. When you check a fermentor in detail, you will come to identify that it has to be sterilized full to obtain the desired results, but on the other hand, the designing of a bioreactor is specific in nature resulting in to be sterilized unfilled.

Bioreactor

A vessel that provides you the facility of carrying out a chemical process involving the organisms or biochemically active substances which are derived from such organisms is called a bioreactor. The shape of most of the Bioreactors is cylindrical that can be obtained in various sizes started from some liter up to cube meters. The most commonly used material for producing a bioreactor is stainless steel. You can say that a bioreactor is considered to be a large scale operation in which volume or capacity can be accessible to several liters. The term of bioreactor is referred to any manufactured or engineered device or system the main target of which is to support a biologically active environment easily and effectively. If you wish to grow cells or tissues in the context of cell culture then the utilization of a bioreactor is the most appropriate way for you in this reference. The employment of the bioreactors can be observed in the tissue engineering and the biochemical engineering.

Fermentor

The device that is able to perform the process of fermentation is known as fermentor. A metabolic process in which the conversion takes place from sugar to acids, gases or alcohol is called fermentaion. The procedure of the fermentation is occurred in the yeast and bacteria in addition to the oxygen-starved muscle cells. The term of the Fermentation has a very broad scope because the process of fermentation is ideal for the bulk growth of microorganisms on a growth medium as well. In the language of science, the fermentation is given a separate name of zymology. The fermenter device is rather small as it only ranges ~2 liters. In order to perform the procedure of the fermentation, you are bound to produce an environment where the oxygen is not present. In old times, fermentation is said to be the most ideal modus operandi for the production of alcohol in which the grains and fruits are fermented to form beer and wine. But nowadays, from the scientific point of view, a metabolic process can be confirmed fermentation in the case when this procedure releases the energy from a sugar or other organic molecules with the absence of oxygen or an electron transport system. In this method, an organic molecule is used as the final electron acceptor and the device which can perform this function is called a fermentor.

While in earlier times, the process of fermentation was mainly used for production of brewing alcoholic beverages only, with the increase in our knowledge about bacteria and fungi, fermentors have been developed that are being put to more productive uses. Bioreactors are a step ahead in design and construction. While fermentors are systems used for growth and maintenance in a controlled manner, of a population of bacterial or fungal cells, bioreactor is a system used for growth and maintenance of mammalian and insect cells. Thus it is clear that there are natural differences between the two, and these differences are enlisted below.

• While mammalian cells are fragile having shear sensitive cell membranes, bacterial cells are robust as they have strong cell walls.

• Mammalian cells are slow in their growth (they have 24 hour doubling time). On the other hand, bacterial cells are fast growing and double in just 20 minutes.

• Insect and mammalian cells have low oxygen demand whereas bacterial cells have a very high oxygen demand

• There is no viral threat in case of bacterial cells whereas this threat is present in case of mammalian cells and has to be either inactivated or removed.

There are differences in sterilization process also. While in the case of a fermentor, it has to be sterilized full, a bioreactor is so designed so as to be sterilized empty.

Bioreactors are large in comparison to fermentors and range in size from a few liters to cubic meters whereas fermentors are typically small having a capacity of up to 2 liters. Bioreactors are cylindrical vessels made of stainless steel.

We have different type fermenter and bioreactor, from lab scale to industrial scale.

We accept customized according to your requirements.

1. Lab scale single vessel fermentor bioreactor

2. Lab scale double vessel fermentor bioreactor

3. Lab scale bowl vessel fermentor bioreactor

4. Lab Scale Fermentor bioreactor Aniaml Cell Vessel

5. Multi-Fermentor bioreactor  SiDoLim 6 

6. In situ sterilizable Fermentor bioreactor 

7. Pilot Scale Fermentor bioreactor 

8. Plant scale fermentor bioreactor system

1. How can you guarantee we receive a good quality?

First, we have Q/C department to control the quality from raw material to the finished products. When the machine was finished, we will send you the inspection video and pictures. Or you can come to our factory to inspect the machine before you arrange the balance of the payment.

2. Do you provide any help about the product operation?

We have English manuals and operational video, which could help you know the operation easily.

3. How about warranty?

We could make sure all of our machines with one year’s warranty and provide you with free technical support of equipment lifelong.

4. How can I get more details about this machine?

Please write all your question in the below mailbox, we will reply to you via E-mail within 12 hours.

SiDoLim, Silver Double Limited is a worldwide leading OEM manufacturer and supplier of measuring instruments and automation solutions for the industrial process, engineering industry, chemicals and petrochemicals industries,and paper making industries, metallurgy and so on, and is focused on providing advanced, state-of-the-art products for our customers. We are also committed to producing cost-effective, accurate, rugged, and reliable monitors and control solutions at reasonable prices.

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