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How BCAAs Help You Keep Your Muscles
Here are the ways branched-chain amino acids can help you stay swole when you're dieting.
Increase Protein Synthesis
Branched-chain amino acids (which are the essential amino acids valine, isoleucine, and leucine) stimulate muscle protein synthesis, potentially more than a normal protein on its own. Protein synthesis is the metabolic process when your body makes new muscle protein, also known as gains.
Reduce Protein Breakdown
Increased BCAA levels also work in your favor by reducing the rate of protein breakdown. They do this by decreasing the activity of the protein breakdown pathway, and also by decreasing the expression of several complexes involved in protein breakdown. (They decrease the amount of mRNA produced from the gene that codes for these components.)
If we revisit our original equation for muscle mass, it's plain to see that increasing synthesis and decreasing breakdown will equate to muscle gain or maintenance.
Amino acid supplementation could also help you get a more intense workout. Branched-chain amino acids compete with the amino acid tryptophan for entry into the brain, where tryptophan can be converted to the neurotransmitter serotonin.
During exercise, serotonin levels rise and can make you feel more fatigued, meaning you won't be able to push as hard.
BCAA supplementation reduces the amount of tryptophan that gets through the blood-brain barrier, and therefore reduces the amount of serotonin produced. This might allow you to work harder, longer, and get more gains.
Scientific Studies Prove The Effectiveness Of BCAAs
Many studies have been conducted to monitor the safety and effectiveness of branched-chain amino acids.
A study at Leeds Metropolitan University in the UK found that supplementing with leucine during a resistance training program enhanced strength performance.1
A team of researchers from the University of Orleans in France found that during a long endurance trial, athletes who took high levels of mixed branched-chain amino acid supplements (including valine, leucine, and isoleucine) reported feeling less tired. Athletes who took the placebo reported feeling more tired and having more memory errors.2
Other reports found that proteins involved in muscle catabolism (exercise-induced muscle breakdown) appeared to be suppressed following BCAA supplementation. The researchers think this is an indirect function of muscle protein synthesis.3
The Graduate School of Bioagricultural Sciences at Nagoya University in Japan also tested the effects of BCAA supplementation. Their findings show that taking BCAA supplements before and after exercise is effective for reducing post-exercise muscle soreness.4
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