High Quality Vitamin k2 mk7 powder Reasonable price

High quality Vitamin k2 mk7 powder CAS 2124-57-4

Introduction

Application

1. Treat vitamin K deficiency bleeding, promote the formation of thrombin, accelerate blood coagulation, and maintain normal blood coagulation time.

In animals, vitamin K2 has biological activity, and both K1 and K3 need to be converted into vitamin K2 to function.All three forms of vitamin K are converted into vitamin K2 in the liver and are absorbed together with vitamin K2 synthesized by gastrointestinal microorganisms.

In the past 40 years, especially in the past 20 years, due to the breakthrough of serum vitamin K and vitamin K deficiency induced protein detection technology, numerous articles about infant bleeding caused by vitamin K deficiency have been reported all over the world, believing that vitamin K deficiency is an important cause of infant bleeding disease and death worldwide.In 1995, the national child death monitoring data showed that intracranial hemorrhage was the seventh cause of infant death in China, with a mortality rate of 77.4 per 100,000.Vitamin K2 preparations can effectively restore thrombin to normal levels and control its bleeding.

Some elderly people also have vitamin K2 deficiency, prothrombin long time phenomenon;Prothrombin can also be reduced when bicarboxycoumarin is overused to prevent thrombosis.In intravenous nutrition, antibiotics were added to the infusion solution, and anticoagulant vitamin K2 was synthesized in the intestinal tract.But derivatives of water-soluble vitamin K3 were converted into activated vitamin K: too slowly and inefficiently.Vitamin Ka absorption is reduced when biliary tract is blocked, and vitamin K2 deficiency can also be produced. Oral or digestive tract supplement must be provided together with bile salt.Some liver diseases, due to the function of incomplete coagulation factor synthesis reduced, supplement vitamin K on coagulation effect is invalid, need to directly supplement vitamin K2.

2. Vitamin Kz can prevent the progression of cirrhosis to liver cancer.

Vitamin K2 supplements for women with viral cirrhosis may help prevent the development of hepatocellular carcinoma, Japanese researchers report in the July 21 jama journal.The preliminary findings need to be confirmed by large-scale clinical studies, and further studies are needed to determine whether vitamin K2 has the same effect on male patients.[3]

3. For the treatment and prevention of osteoporosis, vitamin K2 can promote the generation of bone protein, which can be combined with calcium to generate bone, increase bone density and prevent fractures.

Vitamin K2 promotes calcium metabolism and plays a positive role in the prevention and treatment of osteoporosis.Studies have confirmed that vitamin K can act on osteoblasts, promote the calcification of bone tissue, and inhibit osteoclasts to cause bone absorption, thereby increasing bone density, which can not only prevent but also treat osteoporosis.In January 2012, Beijing jishuitan hospital reported that some countries had approved the use of vitamin K as an osteoporosis drug in clinical practice.

Professor d.roceesvemreer, from Maastricht university in the Netherlands, said that based on data on the use of vitamin K2 supplements in humans, the effect of vitamin K2 was found to be better than that of vitamin K1.

4, with diuresis, strengthen the liver detoxification function, and can reduce blood pressure.

Vitamin K2 has been shown to be beneficial for cardiovascular health in caucasians because it helps regulate the use of calcium ions and promotes the activity of the martxi gla-protein, which inhibiting vascular calcification, Natural said.In a study of more than 4,000 participants in Rotterdam, vitamin K: high intakes were associated with a 50 percent lower risk of heart disease, a 50 percent lower risk of cardiovascular sclerosis-related disease, and a 20 percent lower overall risk of death compared to other groups.

Preparation

1. Biosynthetic pathway (microbial production of vitamin K2 (MK))

(1) microorganisms such as bacillus subtilis and bacillus natto are generally used to produce vitamin K2(35) in the medium of cooked soybean.

(2) extraction of vitamin K2(35) (6-7) (bacillus natto)

To join in natto 2 times volume 95% ethanol, 30 min stirring extraction, leaching extract, 6000 r/min, 30 min, the centrifugal clear liquid on collection, vitamin K2 (35) contained in the ethanol extract, remove ethanol after decompression enrichment, etc. Product is added to the solution of a butanol, intense oscillation extraction vitamin K2 (35) to is a butanol phase, stationary after stratification, absorb organic phase, the vitamin K2 (35) dissolved in this phase, and then, in a rotary evaporator, in N2 gas filling conditions, concentration, after lyophilization get vitamin K2 (35).