Human Bone Sialoprotein I OPN Elisa Kit

Product Overview

Description

Human OPN Elisa Kit

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell adhesion, and migration. Its expression is upregulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

 

SEKH-0001 Human IL-1 alpha Elisa Kit SEKH-0002 Human IL-1 beta Elisa Kit SEKH-0002(HS) Human IL-1 beta Elisa Kit (High Sensitivity) SEKH-0003 Human IL-1F9/IL-36 gamma Elisa Kit SEKH-0004 Human IL-1Ra Elisa Kit SEKH-0005 Human IL-1 RI Elisa Kit SEKH-0006 Human IL-1 RII Elisa Kit SEKH-0007 Human IL-1R4/ST2 Elisa Kit SEKH-0008 Human IL-2 Elisa Kit SEKH-0008(HS) Human IL-2 Elisa Kit (High Sensitivity) SEKH-0009 Human IL-2R Elisa Kit SEKH-0010 Human IL-3 Elisa Kit SEKH-0011 Human IL-4 Elisa Kit SEKH-0011(HS) Human IL-4 Elisa Kit (High Sensitivity) SEKH-0012 Human IL-5 Elisa Kit

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