Human Perforin 1 Pore Forming Protein Perforin Elisa Kit

Product Overview

Description

Human Perforin Elisa Kit

Perforin is a pore forming cytolytic protein found in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin binds to the target cell's plasma membrane, and oligomerises in a Ca2+ dependent manner to form pores on the target cell. The pore formed allows for the passive diffusion of a family of pro-apoptotic proteases, known as the granzymes, into the target cell. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.<br/>Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Perforin is thought to act by creating holes in the plasma membrane which triggers an influx of calcium and initiates membrane repair mechanisms. These repair mechanisms bring perforin and granzymes into early endosomes.

SEKH-0001 Human IL-1 alpha Elisa Kit SEKH-0002 Human IL-1 beta Elisa Kit SEKH-0002(HS) Human IL-1 beta Elisa Kit (High Sensitivity) SEKH-0003 Human IL-1F9/IL-36 gamma Elisa Kit SEKH-0004 Human IL-1Ra Elisa Kit SEKH-0005 Human IL-1 RI Elisa Kit SEKH-0006 Human IL-1 RII Elisa Kit SEKH-0007 Human IL-1R4/ST2 Elisa Kit SEKH-0008 Human IL-2 Elisa Kit SEKH-0008(HS) Human IL-2 Elisa Kit (High Sensitivity) SEKH-0009 Human IL-2R Elisa Kit SEKH-0010 Human IL-3 Elisa Kit SEKH-0011 Human IL-4 Elisa Kit SEKH-0011(HS) Human IL-4 Elisa Kit (High Sensitivity) SEKH-0012 Human IL-5 Elisa Kit

 Our Elisa Kit Lab