- Home
- Categories
- Factory Supply L 5 MTHF Levomefolate Calcium Cas 151533 22 1 L 5 Methylfolate Calcium
Factory Supply L 5 MTHF Levomefolate Calcium Cas 151533 22 1 L 5 Methylfolate Calcium
- Category: >>>
- Supplier: Chengdu Healthlife Biotechnology Co. Ltd. [Sichuan China]Chengdu
Share on (60837160171):
Product Overview
Description
Product Description
Hot Selling Levomefolic Acid, L-5-MTHF, Levomefolate Calcium,L-5-Methyltetrahydrofolate, L-Methylfolate Calcium Powder
Hot Selling Levomefolic Acid, L-5-MTHF, Levomefolate Calcium,L-5-Methyltetrahydrofolate, L-Methylfolate Calcium Powder
L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
It goes by several other common names including:
L-Methylfolate calcium Cas 15133-22-1
Levomefolic acid Cas 31690-09-2;
5-methyltetrahydrofolate Cas 26560-38-3;
It is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
Functions
1. Major depressive disorder.
Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication.
2. Diabetic neuropathy.
Early studies show L-Methylfolate supplementation may be beneficial in treating severe depression and diabetic neuropathy.
3. supplementing L-Methylfolate is the clear alternative while pregnant.
Supplementing with L-Methylfolate while pregnant is the clear alternative for those who suspect an issue with metabolising folic acid.
4. Cardiovascular disease and cancer.
L-methylfolate has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil.
Specifications
| Items | Specifications | Results |
| Appearance | White to yellow powder | White to yellow powder |
| Assay(HPLC)L-isomer | 95.0%~103.0% | 98.60% |
| Specific Rotation (C=1.5% in water, 25℃) | +38.0 to +42.0° | +38.5° |
| Identification(IR;HPLC;Calcium) | IR spectrum /HPLC/ Calcium matches R.S. | Matches R.S. |
| Calcium (Anhydrous basis) | 7.0~8.5% | 7.80% |
| Chloride(Cl) | ≤0.5% | <0.1% |
| Water(KF) | ≤17.0% | 10.20% |
| Residue on ignition | ≤0.1% | 0.02% |
| D-5-Methyltetrahydrofolate | ≤1.0% area | 0.30% area |
| Arsenic (As2O2) | ≤1 ppm | <1ppm |
| Boron | ≤20 ppm | <20ppm |
| Heavy metals (as Pb) | ≤10 ppm | <10ppm |
| Individual impurity | ≤1.0% | <0.21% |
| Total impurities (HPLC) | ≤2.5% | <1.09% |
| Residual solvent(Ethanol) | ≤1000 ppm | <100 ppm |
| Total plate count | ≤100 cfu/g | <10 cfu/g |
| Yeast & Mold | ≤100 cfu/g | <10 cfu/g |
| Salmonella | Negative | Complies |
| E. Coil | Negative | Complies |
| Conclusion: | The above items of the product conform to the standard. | |
Packing & Delivery
Method of Payment
Our Company
Healthlife Biotechnology Co., Ltd. is a pharmaceutical company mainly engaged in export of products including, without limitation, pharmaceutical raw materials both for vet and human, also Vitamins, Amino Acids, minerals, peptides, plant extract, feed and food additives.
Certifications
FAQ
Q1: Can I get some samples?
A: Yes, free samples are available for most of our products, you only need to pay the shipping cost.
Q2: How to confirm the quality before orders?
A: Two ways, either by free samples, or send us the detailed specifications, we will arrange the production as per your requirement.
Q3: What's your MOQ?
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.
Q4: What's the delivery lead time?
A: 2-5 days after payment.
Q5: How about discount?
A: Mainly based on quantity, also some promotional products with special discount from time to time.
Q6: How to contact us?
A: IM: Trademanager, Skype, Whatsapp, Wechat; Call us directly or send us email.
We Recommend
New Arrivals
New products from manufacturers at wholesale prices
