Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.
Application
PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).
It is also active in the condensation reaction in heme synthesis.
PLP plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines.
Function
PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.
In transamination, after deprotonation the quinoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex.
In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine. In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.
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100% payment before delivery
COA offer
Custom Synthesis Products
30% deposit, 70% before delivery
Test report offer
Our Company
Wuhan HengHeDa Pharm Co., Ltd is a hi-tech enterprise locates in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. HengHeDa Pharm has complete administration management and a good work team, which makes it growing fast in chemicals and pharmaceutical industry
FAQ
1. Who we are?
Wuhan hengheda pharm Co., Ltd., located in Wuhan, China, was founded in the year of 2013 by Dr. Zhou
We are now the few professional manufacturers for the series of natural high purity product, such as astragalus extract (Astragaloside IV and Cycloastragenol), Gardenia jasminoides Ellis extract (Genipin, Geniposide and Geniposidic acid) and Galangin in China.
Dr Zhou majored in natural plant chemistry and new chemical synthesis , who was graduated from Shanghai Institute of Biology, Chinese Academy of Science.)
2. Do we have the test reports for our products provided by the independent third party?
Every batch of our product was tested by authorized independent third party, Analysis testing center, Shanghai branch, Chinese Academy of Science. We send goods to customers with test report and COA. Our products were also tested by American Analytical Chemistry Laboratories and Chromadex too.
3. What is our advantage?
The series of natural extracted product are all self-developed, produced and tested. Mature production technology, strict cost control, and perfect quality assurance system, ensure the product stability and competitive price.
4. How we perform an order?
Email inquiry is preferred in our company. We usually give our formal quotation list or formal reply within 24 hours including price, lead time and any other information customer needed. Our quotation is usually valid for three months.
5. What is the minimum order quantity?
No matter how much do you need, we all can supply you with the suitable package, from sample quantity to bulk order.
