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Name:professinal supply ,Tetracycline Hydrochloride,64-75-5
CAS No.:64-75-5
Appearance:White Fine Powder

| Item | Standard | Result | ||||
| Characteristics | A white or yellowish white powder .Odorless or almost.bygroscopic | Conforms | ||||
| Identification | A:B:C The positive reaction. | Conforms | ||||
| Solubility | Very soluble in water, insoluble in acetone , chloroform, ether. | Conforms | ||||
| Specific optical rotation | +53.5°~ +59.0° | +58.0° | ||||
| Acidity of alkalinity | 5.0~7.5 | 6.7 | ||||
| Impurity A | 2%max | Conforms | ||||
| Impurity C | 3% ~15% | Conforms | ||||
| Any other impurity | not more than the area of the principal peak | Conforms | ||||
| in the chromatogram obtained with RS(B)5% | ||||||
| Total other impurity | not more than 3times the area of the principal peak | Conforms | ||||
| in the chromatogram obtained with RS(B)15% | ||||||
| Disregard limit | ae of the principal peak in the chromatogram | Conforms | ||||
| obtained with RS(C)1% | ||||||
| Loss on drying (pct) | max8.0 | 5.0% | ||||
| Sulphate | 27.0-31.0% | 28.4%max | ||||
| Sulphated ash | 1% max | 0.2% | ||||
| Microcount limit test | NMT 500 col/g | 10 col/g | ||||
| Microcount-yeast and molds | NMT 10 col/g | Conforms | ||||
| Microcount-Escherichia coli | Absent | Conforms | ||||
| Microcount-Staphy lococcus aureus | Absent | Conforms | ||||
| Microcount-Pseudo monas | Absent | |||||
| Assay | ≥680I.U./mg (DRY) | 687I.U./mg DRY 653I.U./mg MOIST | ||||

1 This product has a certain antibacterial effect on some anaerobes, but it is far inferior to metronidazole, clindamycin and chloramphenicol, so it is not used clinically. Over the years, due to the extensive application of tetracyclines, Gram-negative bacteria such as Staphylococcus and gram-negative bacilli, such as Staphylococcus, have been extensively drug-resistant to tetracycline.
Moreover, there are cross resistance among the species of the same kind. The action mechanism of this product is that the drug can specifically bind to the A location of the ribosomal 30S subunit, and prevent the binding of aminoyl tRNA on this site, thereby inhibiting the growth of peptide linkage and affecting the protein synthesis of bacteria.
2 The first choice for the treatment of non bacterial infection of Chlamydia, Rickettsia, mycoplasma pneumonia disease, relapsing fever and other infections, but also for the treatment of brucellosis, cholera, tularemia, rat bite fever, anthrax, tetanus, plague, actinomycosis, gas gangrene and sensitive bacterial respiratory system, bile duct, urinary tract infection and skin and soft tissue infec




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