Significant reduction of waist circumference (2 cm)
• Comparing with the placebo group, the hk-BPL1 strain significantly decreased the waist circumference, the waist circumference/heightratio, and the conicity index, where as a borderline significant reduction was observed after BPL1 consumption
• The average reductions in abdominal visceral fat area after BPL1 treatments were of-3.66 cm2 and-7.01 cm2, for the alive and heat-killed cells, respectively, and the latest being significantly related to baseline • Inaddition, diastolic blood pressure and HOMA index were reduced after hk-BPL1 treatment
• Inaddition, diastolic blood pressure and HOMA index were reduced after hk-BPL1 treatment
Changes in the gut microbiome
• Concomitantly with the decrease in obesity biomarkers, treatments with both, live and heat-killed CECT8145 strain increased the incidence of Akkermansia spp.
• The maximum increase in Akkermansia spp. was observed after the administration of the live strain
• There is a general shift to enterotype 1 after the treatment that could be related to the growth promotion of Bacteroides by Bifidobacterium species
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